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Mar 01,2024

REN, Lihua

Ren, Lihua

Assistant professor

Department: Maternal and Child Nursing Department

Tel: 010-82805252

Address: Peking University School of Nursing, No.38 Xueyuan Road, Haidian District, Beijing 100191, P.R. China

E-mail: renlihua@bjmu.edu.cn

Personal Introduction:

Dr. Ren Lihua is an associate professor at Peking University School of Nursing. She has a nursing and preventive medicine interdisciplinary background. Her research mainly involves two fields. On one hand, she focuses on the impact of environmental pollution on reproductive health. From the perspective of early life, she explored the effects of environmental pollutants in early life on the reproductive function of offspring and the epigenetics mechanism. On other hand, she focuses on maternal and child health, mainly focusing on early life health management, and the impact of early life environment on maternal and child outcomes.

Personal profile:

Educational experiences

Sep, 2014~ Jul, 2017 Doctor, School of Public health, Capital Medical University, China

Sep, 2008~ Dec, 2011 Master, School of Nursing, Xinxiang Medical University, China

Sep, 2001~ Jul, 2006 Bachelor, School of Nursing, Jilin University, China

Working experiences

Oct, 2020~ Associate professor, School of Nursing, Peking University, China

Oct, 2017~ Oct, 2020 Postdoctor, School of Nursing, Peking University, China

Jul, 2006~ Aug, 2014 ecturer, School of Nursing, Xinxiang Medical University, China

Research Areas:

Maternal and child health, environment and reproductive health

Selected projects (including title and fund support):

Modification on cardiovascular effects of short-term exposure to black carbon by psychosocial stress and its regulatory mechanism via glucocorticoid secretion and glucocorticoid receptor methylation. Supported by National Natural Science Foundation of China. No: 82073509, 2021-2024 (Co-PI).
The effects of the fine particulate matter on reproduction of male rats in early life stage and the mechanism. Supported by the Fundamental Research Funds for the Central Universities. No: BMU2021YJ020, 2021-2023 (PI)
The transgenerational effects of the fine particulate matter on reproduction of male rats in early life stage and the role of methylation of inhibin. Supported by National Natural Science Foundation of China. No: 81803273, 2019-2021 (PI).
The effect and mechanism of PM2.5 on spermatogenesis by miR-200b-3p-mediated autophagy. Supported by China Postdoctoral Science Foundation. No:2018M641119, 2018-2020 (PI)
Effect of PM2.5 exposure during pregnancy on birth weight and regulation mechanism of thyroglobulin hydrolase. Supported by LANGTAI Nursing Research Fund. No: LTHL18MS01, 2018-2019 (PI)

Selected publication (no more than 10 papers) :

Qi-Fang Huang, Yin-Chu Hu, Chong-Kun Wang, Jing Huang, Mei-Di Shen, Li-Hua Ren*. Clinical First-Trimester Prediction Models for Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis. Biological Research For Nursing 2022, Vol. 0(0) 1–13 （Q2）
Jianhui Liu, Jing Huang, Leqiang Gao, Yujian Sang, Xiangyang Li, Guiqing Zhou, Linlin Cao, Hong Lu, Xianqing Zhou*, Lihua Ren*. Maternal exposure to PM2.5 disrupting offspring spermatogenesis through induced sertoli cells apoptosis via inhibin B hypermethylation in mice. Ecotoxicology and Environmental Safety, 2022 Jun; 241: 113760. (IF=7.129)（Q1）
Lihua Ren, Jianjun Jiang, Jing Huang, Yu Zang, Qifang Huang, Lianshuang Zhang, Jialiu Wei, Hong Lu*, Shaowei Wu, Xianqing Zhou. Maternal exposure to PM2.5 induces the testicular cell apoptosis in offspring triggered by the UPR-mediated JNK pathway. Toxicology Research, 2022,11(1):226-234. （Q2）
Guiqing Zhou #, Lihua Ren#, Haiping Yin, Jianhui Liu, Xiangyang Li, Ji Wang, Yanbo Li, Yujian Sang, Yanzhi Zhao*, Xianqing Zhou*, Zhiwei Sun. The alterations of miRNA and mRNA expression profile and their integration analysis induced by silica nanoparticles in spermatocyte cells. NanoImpact, 2021, 23 :100348. (IF=6.038)（Q1）
Lihua Ren, Jing Huang, Jialiu Wei, Yu Zang, Yang Zhao, Shaowei Wu, Xiaohong Zhao, Xianqing Zhou, Zhiwei Sun, Hong Lu*. Maternal exposure to fine particle matters cause autophagy via UPR-mediated PI3K-mTOR pathway in testicular tissue of adult male mice in offspring. Ecotoxicology and Environmental Safety. 2020 Feb;189:109943. (IF=7.129)（Q1）
Lihua Ren, Jianhui, Liu, Jialiu Wei, Yefan Du, Kaiyue Zou, Yongyang Yan, Zhihao Wang, Linruo Zhang, Tong Zhang, Hong Lu, Xianqing Zhou*, Zhiwei Sun. Silica nanoparticles induce unfolded protein reaction mediated apoptosis in spermatocyte cells. Toxicology Research, 2020 Jul 3;9(4):454-460.（Q2）
Ren L, Liu J, Zhang J, Wang J, Wei J, Li Y, Guo C, Sun Z, Zhou X*.Silica nanoparticles induce spermatocyte cell autophagy through microRNA-494 targeting AKT in GC-2spd cells. Environment Pollution. 2019 Sep 11; 255:113172. (IF=9.988) （Q1）
Ren L, Zhang J, Wang J, Wei J, Liu J, Li X, Zhu Y, Li Y, Guo C, Duan J, Sun Z, Zhou X*. Silica nanoparticles induce spermatocyte cell apoptosis through microRNA-2861 targeting death receptor pathway. Chemosphere. 2019, 228:709 -720. (IF=8.943) （Q1）

Membership (academic):

Expert of National Graduate Education Evaluation and Monitoring Expert Database

Standing member, Environmental and Reproductive Health Branch, China Eugenics Association

Vice President, Beijing International Ecology and Economy Association

Member of Chinese Nursing Association

REN, Lihua

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